For example, grape juice extract has shown the inhibition of MMP-2 and MMP-9 gene expression in CRC HT-29 and SW480 cells [57], and the natural selenium polysaccharide in Pleurotus ostreatus could upregulate the expression of E-cadherin and downregulate the expression of Vimentin in HCT116 cells and gastric cancer MGC-803 cells [58]. This evidence concerns the gene VIM and colorectal carcinoma.