-Activating the Nrf2-ARE signaling pathway. Nrf2 is a transcription factor that plays a key role in cellular defense mechanisms by regulating the expression of antioxidant and detoxification genes.-Activation of the Nrf2-ARE pathway by sesaminol could enhance the cellular defense against oxidative stress, which is implicated in the pathogenesis of Parkinson’s disease.-Dysfunction in mitochondrial activity; through its antioxidant and cytoprotective effects, it may contribute to the preservation of mitochondrial function in neurons. This evidence concerns the gene NFE2L2 and Parkinson disease.