BCR and chronic myelogenous leukemia, BCR-ABL1 positive: It is well known that chronic myeloid leukemia (CML) is associated with chromosomal translocation (i.e., Philadelphia chromosome), which encodes the BCR: ABL1 oncoprotein through the fusion of the BCR and ABL1 genes with active tyrosine kinase activity, so tyrosine kinase inhibitors (TKIs) are currently the cornerstone treatment of CML.