Higher platelet count in overt fibrotic patients was significantly associated with male sex, lower grade of bone marrow fibrosis, absence of constitutional symptoms, lower spleen size, higher WBC, higher monocyte and basophil count, hemoglobin, lower CRP, higher serum uric acid, presence of chronic kidney disease and hyperlipoproteinemia, absence of diabetes mellitus, use of cytoreductive therapy, lower DIPSS among PMF and lower Mysec-PM among SMF patients (p < 0.05 for all analyses). The gene discussed is CRP; the disease is primary myelofibrosis.