Among prefibrotic PMF patients, higher ANC was significantly associated with older age, JAK2 mutation, absence of CALR mutation, present constitutional symptoms, higher WBC, higher ALC, monocyte and basophil count, higher lactate dehydrogenase (LDH), serum uric acid, Charlson comorbidity index, presence of chronic kidney disease and use of cytoreductive therapy (p < 0.05 for all analyses). Here, CALR is linked to chronic kidney disease.