CRP and Splenomegaly: Higher platelet count in prefibrotic PMF patients was significantly associated with male sex, higher grade of BM fibrosis, absence of overt MF clinical features (constitutional symptoms, transfusion dependency, massive splenomegaly, larger spleen size, circulatory blasts), lower C-reactive protein (CRP) and use of cytoreductive therapy (p < 0.05 for all analyses).