Regarding etiopathogenesis, an important contribution to the understanding of AD was recently offered by explainable AI, by which the dysregulation of the inhibitor of nuclear factor kappa B kinase subunit beta- nuclear factor kappa-light-chain-enhancer of activated B cells (Ikkb-NF-kB) axis in the paired related homeobox-1 (Prx1)+ fibroblastic subpopulation promoting skin inflammation by the overexpression of eotaxin-1 could be identified as a new unknown etiologic factor [10]. This evidence concerns the gene PRRX1 and Alzheimer disease.