CYP27A1 and CYP27B1 are expressed in MeWo, SK-Mel28, SM, SK-Mel-5, SK-Mel-25, IGR, and MelJuso melanoma cell lines; however, the last four cell lines in this list are not responsive to 25(OH)D3 and calcitriol treatment [60]. This evidence concerns the gene CYP27B1 and melanoma.