In LPS-stimulated microglia, TAN exerts an antioxidant impact by reducing ROS production while boosting heme oxygenase-1 (HO-1) expression [121] via the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, which is one of the therapeutic targets of PD [122]. The gene discussed is HMOX1; the disease is Parkinson disease.