TCF7L2 and diabetes mellitus: As diabetes is a condition linked to increased cardiovascular risk (Table 2 and Figure 3), it was unsurprising that our work revealed gene interaction between KLFs, particularly KLF-14, and genes associated with diabetic risk factors, such as CAMK1D, HHEX, JAZF1, and TCF7L2 (Table 1 and Table S2).