This resulted in the identification of KLF-4 interactions with genes like GATA4, MEF2C, TBX5, NKX2.5, and SRF (Table 1, Table 2 and Table S2, Supplementary Figure S2), all of which are known regulators of cardiac hypertrophy and pro-hypertrophic pathways [37,38,39]. This evidence concerns the gene MEF2C and cardiac hypertrophy.