For example, the CCL2/MCP-1 axis activates nuclear factor kappa β (NF-kβ) signaling, inducing inflammation and cancer initiation while modulating macrophages into M2-like phenotype TAMs [14] Furthermore, IL-6 inhibits the original phagocytic function of macrophages via the JAK/STAT3 pathway [15], while IL-10 elevates arginase expression and induces M2-like immunosuppressive activity in macrophages [3]. The gene discussed is CCL2; the disease is cancer.