The convergence of these two pathways activates signals such as NF-kβ and hypoxia-inducible factor (HIF-1α) with STAT3 in tumor cells, which causes monocyte recruitment and the production of pro-inflammatory signals such as IL-10 or TGF-β in the TME via M2-like TAMs [15,24]. The gene discussed is TGFB1; the disease is neoplasm.