Risk factors for metastatic death include male sex; older age; larger tumor diameter; greater tumor height; ciliary body involvement; extraocular spread; epithelioid melanoma cell type; extravascular matrix patterns such as closed loops; greater tumor volume; chromosome 3 loss (i.e., monosomy 3); chromosome 8q gain; and several other factors, such as class 2 gene expression profile, BAP1 loss, PRAME expression, and SF3B1 mutation [2,3,4,5,6,7,8,9,10,11]. This evidence concerns the gene PRAME and neoplasm.