EPHX2 and neuroblastoma: In both an inducible MYCN model using SK-N-AS cells (Bandino et al., 2014 [68]) and the tyrosine hydrolase-MYCN (TH-MYCN) mouse model of NB driven by a human MYCN transgene, we observed that MYCN expression resulted in reduced levels of ALOX5, COX2, EPHX2, and CYP4V2 (murine Cyp4v3) (Figure 6d), suggesting that MYCN may play a role in ARA metabolism.