Long intergenic non-protein coding RNA (Linc-pint), a p53 transcriptional target, was observed to substantially decrease in plasma and tumor of PDAC patients, compared to healthy tissues, carcinoma of the ampulla of Vater (CAV) and cholangiocarcinoma (CCA), indicating its great potential in distinguishing PDAC from possible adjacent cancers. Here, TP53 is linked to cholangiocarcinoma.