CD44 and familial pancreatic carcinoma: The suppression of CD44 expression using shRNA in pancreatic cancer cells led to reduced cellular proliferation and migration, thereby impeding tumor growth and progression, consistent with decreased levels of p-ERK and p-AKT.290 Monoclonal antibodies against CD44 (anti-CD44), such as H4C4, can significantly attenuate the stem cell self-renewal genes Nanog, Sox-2, and Rex-1, as well as regulating STAT3 signaling, thereby inhibiting the post-radiation recurrence in mice xenografts [253].