Long intergenic non-protein coding RNA (Linc-pint), a p53 transcriptional target, was observed to substantially decrease in plasma and tumor of PDAC patients, compared to healthy tissues, carcinoma of the ampulla of Vater (CAV) and cholangiocarcinoma (CCA), indicating its great potential in distinguishing PDAC from possible adjacent cancers. This evidence concerns the gene TP53 and carcinoma of the ampulla of vater.