The variability of the Th2 response in different preclinical tumor models may be in part due to plasticity between Th1 and Th2 polarization, with factors such as VEGF shown to repolarize T cells from a Th1 to a Th2 phenotype [36], while PD-1 blockade has been shown to revert the Th2 to Th1 phenotype [37]. The gene discussed is VEGFA; the disease is neoplasm.