This discordance between the dependence of Th2 function on caspase 8 and an association between CASP8 mutation and Th2 infiltrate may be at least partially explained by cancer-associated missense mutations in CASP8 associated with epithelial cancers that inhibit its apoptotic function but chronically activate NF-κβ signaling [42]. This evidence concerns the gene CASP8 and cancer.