The comparison between recurrent HPV insertional targets and tumor localizations showed that all of the insertions at MYC (13), FHIT (7), and VMP1 (12) were found in genital tumors and were preferentially associated with HPV18/45, whereas the insertions on ACTL7B (6/6), CD274 (7/8), and PLGRKT (4/6) were mainly found in HNCC cases (one CD274 insertion in anal cancer) and preferentially associated with HPV16. The gene discussed is FHIT; the disease is neoplasm.