The literature search and/or the CRISPR screen allowed us to further classify some of these genes as oncogenes (AKR1C3, TUBD1, and VMP1), tumor suppressors (LEPREL1), or genes with dual pro- and anti-tumor effects (FAM110B, KLF12, and MAGI2), while others were found to act in the tumor process as transcription factors (NAALADL2, NFIA, NFIX, and NR4A2), cell adhesion (CEACAM5/6), cell proliferation (TPRG1), matrix modeling molecules (PLGRKT), or immunoevasion (MAPK10 and CXCL8). This evidence concerns the gene NAALADL2 and neoplasm.