MSH6 and Inherited cancer-predisposing syndrome: Given a family size of three generations with 2–4 children per generation and using a panel of the 18 most common genes associated with hereditary cancer syndromes (including the three mismatch repair genes MLH1, MSH2, and MSH6), it would take 9.9 years to detect all carriers using the provider-mediated approach if 70% of the first-, second-, and third-degree relatives were tested.