AKT1 and cancer: ERα36 has also been found to transduce estrogen-dependent activation of the MAPK/ERK and PI3K/AKT signaling pathways, as well as the PKCδ/ERK signaling pathway, which are of importance for malignant properties of cancer, such as cell proliferation, metastatic potential, and protection against apoptosis [47,48,49,50,51].