PECAM1 and neoplasm: Moreover, Myoung et al. have demonstrated a down-regulation in VEGF mRNA expression after the genistein treatment (27.3 μg/mL) in HSC-3 cells, reduced tumor invasion through the artificial basement membrane and gelatinolytic activity compared to the control group, while in HSC-3-bearing mice treated with 0.5 mg/kg genistein, lower CD31 immunoreactivity was determined, with no difference in the tumor growth and metastatic behaviour [140].