Furthermore, ERβ was expressed in the majority of laryngeal carcinomas (83%) and its expression is in a positive correlation with the maintenance of E-cadherin and ß-catenin at cell junctions of the tumor cells plasma membrane and a negative correlation with the increased TNM stage, nuclear translocation of β-catenin, and loss of the E-cadherin [97]. This evidence concerns the gene ESR2 and laryngeal carcinoma.