Interestingly, in most studies of oral squamous cell carcinoma (OSCC), ERβ was described as a predominantly expressed sub-type of nERs [81,82,83,84], although there are contradictory results in other studies where ERα expression was predominant over ERβ in both oral cavity and laryngeal/hypopharyngeal cancers [85]. Here, ESR2 is linked to hypopharynx cancer.