TAMs in the TME are more often M2 macrophages which secrete interleukins IL-4, IL-5, IL-6, and IL-10, known to promote tumor cell growth and immune evasion [176,177], and the highest concentration of TAMs in TIME of high-grade serous ovarian carcinomas was found in ERα-positive tumors [178]. The gene discussed is ESR1; the disease is neoplasm.