Finally, the alterations observed in our HNSCC cohort echo a previously reported dataset in which CASP8, TERT, and NOTCH1 were also frequent co-mutations in HRASmt HNSCC, while CCND1 had higher amplification in HRASwt compared to HRASmt [20] (Figure 2). This evidence concerns the gene CASP8 and head and neck squamous cell carcinoma.