In glioma U87 cells, the inclusion of riluzole in in vitro cultures and in vivo xenografts led to the suppression of mGluR1 signaling and significant decreases in tumor cell proliferation, potentially through reduced phosphorylation of PI3K, AKT, mTOR and P70S6K, and this has been confirmed in several studies [196]. This evidence concerns the gene AKT1 and neoplasm.