The activation of Src family kinases, as well as various GTPases (e.g., RhoA, Ras, and Rac1), drives intracellular signaling pathways, such as the Ras-MAPK and PI3K/Akt pathways, that promote tumor cell-specific processes, including chemoresistance [82,87,88]. The gene discussed is AKT1; the disease is neoplasm.