Additionally, FXa/PAR2 signaling in tumor-associated macrophages is discussed in the secretion of immunosuppressive mediators, and FXa inhibition is shown to increase the population of cytotoxic T-cells with tumor-killing ability while reducing the Infiltration by immunosuppressive cells, MDSCs, and Treg in the TME [141]. This evidence concerns the gene F10 and neoplasm.