Thrombin also triggers the release of TNF-α from monocytes, adipose cells, vascular smooth muscle cells, and monocyte-derived macrophages [127], which facilitates tumor immune evasion in multiple ways: it (1) promotes the accumulation and activity of the negative regulatory cells of the tumor immune response, such as Treg cells [129], MDSCs [130], and regulatory B-cells (Breg cells) [131], (2) interferes with the tumor infiltration of cytotoxic T-cells [132,133], and (3) induces the activation-triggered death of cytotoxic T-cells [134]. This evidence concerns the gene TNF and neoplasm.