TF/FVIIa/PAR2 signaling induces the release of nano-sized microvesicles (MVs) from human highly metastatic breast cancer cells [93], which are enriched with microRNA221 (miR-221), and the MV-mediated transfer of miR-221 confers proliferative, metastatic, and anti-apoptotic potential to non-metastatic breast cancer cells via the induction of EMT [85,94]. This evidence concerns the gene TF and breast cancer.