Using a dataset obtained from the Chinese glioma genome atlas (CGGA) and the cancer genome atlas (TCGA), Wang, LJ et al. proposed a prognostic model of HGGs based on the expression profiles of seventeen S100 family genes (including S100A4) in relation to the tumor microenvironment [107] (Figure 11A–G) (Table 2). The gene discussed is S100A4; the disease is neoplasm.