In particular, in a study including 366 MDS patients, 20 genes were mutated in almost one-third of HR and very HR R-IPSS patients, with the most prevalent being KDM6A, CEBPA, TP53, ASXL1, RUNX1, DNMT3A, SH2B3, and BCOR [50]. This evidence concerns the gene TP53 and myelodysplastic syndrome.