RB1 and small cell lung carcinoma: Notably, in support of the findings from Tu J. et al., the synthetic lethality screening performed by Oser MG et al. also identified that the depletion of RNA splicing factors, such as SNRPG, SNRPF, and U2AF1, leads to synthetic lethality in RB1-deficient small cell lung cancers (SCLCs) [52].