Growing evidence suggests a connection between ferroptosis and cancer cells that are resistant to therapies or drugs, observed in pancreatic ductal adenocarcinoma, small cell lung cancer (SCLC), triple-negative breast cancer, etc. Wang ME et al. demonstrated that the mechanistic association of ferroptosis links to RB1 tumor suppressor loss and RB1-regulated transcription to targeted therapy [65]. Here, RB1 is linked to pancreatic ductal adenocarcinoma.