RB1 and cancer: We highlight nine potential pharmacological strategies in RB1-deficient cancers: inhibition of spliceosomal mechanisms, Aurora Kinase inhibition, PARP inhibition, ferroptosis induction, SKP2 ubiquitin ligase inhibition, histone demethylase LSD1 inhibition, histone methyltransferase DOT1L inhibition, ESRRG inhibition, and arginine methyltransferase PRMT5 inhibition.