MTOR and glioblastoma: A great number of studies on Akt pathway, which in its expanded version includes phosphatidylinositol 3-kinase (PI3K)/Akt/rapamycin-sensitive mTOR-complex (mTOR) signaling [102] have reported the frequency of mutations and copy number aberrations of its components in glioblastoma to be around 88% [102,103].