CXCL12 and neoplasm: In addition, the infiltration of TAMs in tumors was mediated by numerous chemotactic factors produced by tumor cells including C-C motif ligand 2 (CCL2), CX3C chemokine ligand 1 (CX3CL1), stromal cell-derived factor-1 (SDF-1), colony-stimulating factor-1 (CSF-1) and periostin (POSTN), among many other molecules augmented in present studies [76].