The mechanism underlying the cytotoxic effects of curcumin on several breast cancer cell lines in relation to PI3K/Akt signaling has been investigated by Hu et al. Their team used seven different cell lines, and the results showed a differential susceptibility to curcumin treatment between ER+ breast cancer cells, including MCF-7, T4FD, MDA-MB-415, and ER-PR-HER2 cells, such as MDA-MB-231 and BT-20. This evidence concerns the gene PIK3CA and breast carcinoma.