The interaction among curcumin, 14-3-3 proteins, and the PI3K/Akt signaling pathway has also been investigated in A549 lung cancer cells; 14-3-3 proteins are important regulators of Bcl-2 family members, including Bad, Bax, and Bid, and they are often upregulated in different cancer cell lines. The gene discussed is PIK3CA; the disease is cancer.