GJB1 and hepatocellular carcinoma: After proving the cytoplasmic overexpression of Cx32 in HCC tissues and its positive correlation with poor prognosis, as it was observed by other studies described herein, they silenced Cx32 expression in HepG2 cell lines (which normally present high Cx32 expression levels) and increased Cx32 expression in SMMC-7721 cell lines (which normally present low Cx32 expression levels), observing a reduced expression of the apoptosis inhibitor when Cx32 expression was increased in the first case and an increased Bcl-2 expression in the second case [126].