After HCC specimens’ exposure to shikonin (SHN), which induces necroptosis, it was shown that overexpressed Cx32 increased the SHN-induced interaction of RIPK1-RIPK3 and membrane translocation of MLKL, resulting in the formation of necrosome and membrane damage, while Cx32 downregulation alleviated necroptosis [127,137,138,139]. Here, RIPK1 is linked to hepatocellular carcinoma.