GJB1 and liver disorder: Cx32 expression levels in HCC vary regarding tumor characteristics, being negatively correlated with histological grade and lymph node (LN) metastasis; however, no correlation between Cx32 expression and age, gender, tumor size, TNM stage, history of liver disease, vascular embolus, chronic HBV or HCV carriage, tumor necrosis, or tumor hemorrhage has been established [66].