Another study, conducted by Ogawa et al. using HCC cell lines (HSU-C1, -C5F, -C6, -N1, and -L2) and mouse models (inoculated with HSU- C1, -C5F, -C6, -N1, and -L2 cells), investigated the possible regulation of invasion and metastasis in HCC by Cx43 expression [151]. The gene discussed is GJA1; the disease is hepatocellular carcinoma.