Considering the role of caspase 8 in regulating apoptosis by activating downstream caspase cascades and in inhibiting necroptosis by cleaving RIPK1, Xiang et al. proved that Cx32 activates necroptosis in HCC cells via mediating the inactivation of caspase 8 [72,140,141]. Here, RIPK1 is linked to hepatocellular carcinoma.