NRP1 and neoplasm: In particular, GLUT1 and NRP1 are both involved in glucose metabolism: GLUT1, when overexpressed, accelerates the glucose uptake, thus providing sufficient raw materials for glycolysis; NRP1, if overexpressed, can increase the expression and activity of glycolytic metabolizing enzymes and accelerate glycolysis, thus promoting tumor cell proliferation [43,44,49,50].