Public data showed that HMGB2 mRNA expression was significantly higher in the “cellular tumor”, than in the surrounding infiltrative areas [21], and that proneural glioblastomas (which are usually associated with IDH mutations) [29,31] had higher HMGB2 expression than mesenchymal and classical glioblastomas (Supplementary Figure S4). Here, HMGB2 is linked to neoplasm.