To our knowledge, we have shown for the first time that DNA methylation of CpG islands located at the body of HMGB2 (cg19371349, cg21499459, cg08269316) also, at least in part, regulates HMGB2 expression and is strongly associated with OS in grades 2 and 3 gliomas. The gene discussed is HMGB2; the disease is central nervous system cancer.