Importantly, in the areas representative of the infiltrative edge, HMGB2 expression was sometimes cytoplasmic in tumor cells, while being mostly absent from non-neoplastic oligodendrocytes, astrocytes, and neurons (Figure 4f–l), both in GBMs and in grades 2 and 3 and A4 IDHmut. Here, HMGB2 is linked to neoplasm.