TP53 and central nervous system cancer: HMGB2 was reported to be part of the canonical pathway Retinoblastoma gene in cancer (WP2446) [24,25], recently incorporated in the p21-p53-RB pathway [26], and is involved in DNA double-strand break repair Therefore, it contributes to resistance to the standard treatment of gliomas with radiation (RT) [27] and temozolomide (TMZ) [28].