Those molecular GBMs had HMGB2 mRNA expression significantly higher than the other confirmed grades 2 and 3 astrocytomas and oligodendrogliomas (Figure 3c), including “low-grade IDHwt astrocytomas” without other molecular alterations, which would now be classified as glioma, NEC. The gene discussed is HMGB2; the disease is astrocytoma (excluding glioblastoma).