In contrast, we showed with multiple methods that increased HMGB2 expression identifies grades 2 and 3 gliomas with molecular alterations of GBM and A4 IDHmut (“molecular glioblastomas”) before the histological development of necrosis and microvascular proliferation takes place, and it is strongly associated with OS in public and institutional cohorts. Here, HMGB2 is linked to central nervous system cancer.