On multidrug-resistant cancer cells, Hsp90 was shown to induce the expression of ABC transporters, such as P-gp, and the anti-apoptotic proteins survivin and Bcl-2, contributing to a lowered sensitivity to chemotherapeutics and apoptosis, whereas, in the case of Hsp90 inhibition, the observed effects were the opposite [181]. Here, BIRC5 is linked to cancer.