These lesions are most commonly sporadic but can also be a part of genetic syndromes such as Multiple Endocrine Neoplasia 1 (MEN1), Von Hippel-Lindau disease VHL, Neurofibromatosis1 (NF-1), and Tuberous Sclerosis (TSC) [23]. The gene discussed is NF1; the disease is von Hippel-Lindau disease.