The degree to which EGFR, PI3K, NFKβ, JAK-STAT, CK2, WNT, NOTCH, Hedgehog, and TGFβ are dependent on each other, and redundant with each other, in the context of glioblastoma therapeutics remains to be fully elucidated. This evidence concerns the gene NFKB1 and glioblastoma.