The degree to which EGFR, PI3K, NFKβ, JAK-STAT, CK2, WNT, NOTCH, Hedgehog, and TGFβ are dependent on each other, and redundant with each other, in the context of glioblastoma therapeutics remains to be fully elucidated. The gene discussed is TGFB1; the disease is glioblastoma.