It has been reported that the risk of gastric neoplastic lesions in cases with vacAs1m1 genotype infection increases from 1.75 (95% CI: 1.04 to 2.96)-fold to 4.8 (95% CI: 1.71 to 13.5)-fold given the detection of a cagA+ gene-positive status. The gene discussed is S100A8; the disease is infection.