Our findings revealed that the H. pylori strains circulating in our environment present a higher frequency of genotypes documented as risk variants for neoplastic lesions, and that their distribution was observed both for cases with CNAG and for cases with IM, highlighting that in Peruvian patients with dyspepsia who present H. pylori infection, the presence of risk polymorphisms for the cagA and vacA genes is related to the clinical stage of preneoplastic IM lesion. This evidence concerns the gene S100A8 and dyspepsia.