Upregulation of PDL-1 and downregulation of MHC-I-class molecules are particularly relevant, as these two mechanisms complement each other, allowing melanoma cells to evade MHC-I-restricted killing by tumor-specific cytotoxic CD8+ T cells and instead render them dysfunctional via the PD-1/PDL-1 pathway. The gene discussed is CD274; the disease is neoplasm.