Finally, CodeBreak 101 (NCT041185883) is an ongoing phase Ib/II study testing the efficacy and safety of sotorasib in combination with targeted molecules, such as EGFR, SHP2, mTOR, and CDK inhibitors, but also with chemotherapy and immune checkpoint inhibitors (ICIs) in advanced KRAS-G12C-mutated lung cancer [60]. This evidence concerns the gene KRAS and lung cancer.