GSK3B and obesity due to melanocortin 4 receptor deficiency: The signalling molecules involved were reduced phosphorylation of GSK3β as well as downregulation of downstream genes of the NRF2 signalling pathway, including nicotinamide-adenine dinucleotide phosphate hydrogen quinone dehydrogenase 1 (NQO1) and HO-1 in high-fat diet fed obesity-prone rats.