Furthermore, the inflammatory background, substantiated by the assessment of IL-17A, IL-18, IL-10, TNFα, and ICAM-1, and the instrumental intervention of mtDNA in early DKD and cerebrovascular remodeling were cornered by the significant correlations of these parameters with biomarkers of podocyte damage and PT dysfunction, as well as with cerebrovascular hemodynamic indices, even in the normoalbuminuric stage of DKD. This evidence concerns the gene ICAM1 and diabetic kidney disease.