N-acetylcysteine (NAC) inhibits glioblastoma cell proliferation, migration, and invasion and promotes Notch2 degradation, possibly through an Itch-dependent lysosomal pathway, while decreasing mRNA and protein levels of its downstream target genes, Hes1 and Hey1, thereby inducing apoptosis [174]. This evidence concerns the gene NOTCH2 and glioblastoma.