NLRP3 and metabolic disease: The NLRP3 inflammasome, the so far most studied inflammasome involved in metabolic disorders, consists of a protein-nucleotide-binding domain and a leucine-rich repeat NLR family pyrin domain containing 3 protein (NLRP3) or cryopyrin, an apoptosis speck-like protein containing CARD, and the pro-caspase protease caspase-1 [58].