Similar results were obtained in the work of Misra et al., who showed that the constitutive interaction of the hyaluronan with its CD44 receptor in MCF-7/Adr human breast carcinoma cells activates the PI3K pathway, enhancing the expression of ABCB1/MDR1 and thus contributing to treatment resistance [42]. The gene discussed is PIK3CG; the disease is breast carcinoma.