SOX2 and urothelial carcinoma: On the other hand, and consistently with our data, Abugomaa et al. report oppositely directed expression dynamics for Cd44 and Sox2 during a 3- to 2D transition in canine urothelial carcinoma-derived organoids, a 20- to 35-fold increase for Cd44 (depending on the strain) and a 20-fold decrease for Sox2 [36].