This observation is consistent with published data that in brain tumors the expression of E-cadherin is suppressed, while the level of N-cadherin is up-regulated; immunohistochemistry performed in 60 human ependymomas revealed about 77% of N-cadherin-positive and only 2% of E-cadherin-positive cases [28]. The gene discussed is CDH1; the disease is brain neoplasm.