Treatment of LN-18shSCR and LN-18shSRGN GBM cells with TGFβ1 to trigger TGFβRI signaling markedly induced the expression of SRGN, IL-8, MMP-9, MMP-14, uPA and PAI-1 in control LN-18shSCR cells, whereas only a minor induction in the expression of IL-8 and uPA was noticed in LN-18shSRGN cells (Figure 3 and Figure S3). The gene discussed is MMP9; the disease is glioblastoma.