Our study shows that GBM tissues are enriched in SRGN, inflammatory molecules and proteolytic enzymes and inhibitors including TGFβ1, TGFβRI, IL-8, CCL-2, IL-1β, CXCL-1, IL-6, CCL-20, CXCR-2, MMP-14, MMP-9, MMP-2, MMP-1, uPA and PAI-1 compared to LGG and non-tumor brain tissues. Here, SERPINE1 is linked to neoplasm.