CXCR-2 ligands include CXCL-1, CXCL-2, CXCL-3, CXCL-5, IL-6, CXCL-7 and IL-8 [70,71], and overall CXCLs/CXCR-2 pathway is implicated in cancer and inflammation. The gene discussed is CXCL1; the disease is cancer.