SRGN can mediate the activation of multiple tumor-promoting cascades including immune system response [22,23], the expression and activity of proteolytic enzymes [24,25] and pro-tumorigenic signaling enhancing tumor cell properties such as invasion, metastasis, stemness, epithelial to mesenchymal transition (EMT) and ECM remodeling [21]. Here, SRGN is linked to neoplasm.