In our pursuit to understand the molecular mechanisms behind these changes, our attention was drawn to EZH2, an important regulator of gene expression whose effects are similar to the phenotypic changes observed in the KO cells, and the Cancer Genome Atlas (TCGA) database revealed that the EZH2 expression was 2.4 times higher in colon cancer compared to normal cells [50]. This evidence concerns the gene EZH2 and colonic neoplasm.