In order to discuss MASH pathogenesis involving BDNF, it is necessary to consider both of the following possible mechanisms: the pathological phenotype of the liver might be one of the metabolic dysfunctions associated with overeating due to BDNF reduction in the brain (CNS-mediated effects of BDNF) or the phenotype might be induced by low BDNF expression in peripheral tissue other than the brain (non-CNS mediated effects of BDNF). This evidence concerns the gene BDNF and metabolic dysfunction-associated steatohepatitis.