BDNF and metabolic dysfunction-associated steatohepatitis: And as a mechanism, we found that loss of hnRNPU stimulates the expression of TrkB-T1, which promotes inflammatory signaling and stress-induced cell death in hepatocytes and BDNF administration protected mice from diet-induced MASH by reducing membrane TRKB-T1 protein, promoting liver damage and the emergence of disease-specific signaling patterns that exacerbate the pathogenesis of MASH.