TRPC6 and cardiac hypertrophy: In rodents, an increased expression has been noted in failing cardiac left ventricles of spontaneously hypertensive rats [19], but studies using a pressure overload model of cardiac hypertrophy have implicated TRPC1 [10], TRPC3 [9,20], and TRPC6 [21] in pathogenesis, whilst TRPC5’s expression was reported to be unchanged [9,10].