In the context of colorectal cancer (CRC), the secretion of C-X-C motif chemokine ligand 1 (CXCL5) secreted by CAFs binds to C-X-C chemokine receptor type 2 (CXCR2) on tumor cells, activating the PI3K/AKT signaling pathway. The gene discussed is PIK3CA; the disease is neoplasm.