For instance, Kirsten rat sarcoma viral oncogene homologue (KRAS) is frequently mutated in pancreatic, colorectal, lung, and biliary cancers, while Harvey rat sarcoma viral oncogene homolog (HRAS) and neuroblastoma RAS viral oncogene homolog (NRAS) exhibit a higher frequency of mutations in salivary gland tumors and melanoma [37]. This evidence concerns the gene HRAS and melanoma.