To uncover whether LXR agonism remains anti-atherogenic under low-fat feeding conditions, in the current study, we evaluated the effect of chronic treatment with the pan LXR agonist T0901317 (EC50~50 nM for both LXR-alpha and LXR-beta subtypes [18]) on chow-diet-fed hypercholesterolemic atherosclerosis-susceptible apolipoprotein E (APOE) knockout mice. The gene discussed is APOE; the disease is atherosclerosis.