In the current study, we extended our studies on the effect of currant consumption in AD-related pathogenic processes by examining whether a currant-supplemented diet, as compared to control and sugar-matched diets, could affect the activity of the antioxidant enzyme PON1 and levels of oxidation markers in serum and the brain of the same groups of 5xFAD mice studied previously [22]. This evidence concerns the gene PON1 and Alzheimer disease.