The reported sexually dimorphic effects of perturbing BDNF signaling should also be more carefully explored. Considering the significant prevalence of obesity and mutations affecting BDNF signaling within the human population [121], elucidating the mechanistic outcomes of BDNF/TrkB signaling affecting energy and glucose balance is essential. Here, NTRK2 is linked to obesity due to melanocortin 4 receptor deficiency.