NTRK2 and obesity due to melanocortin 4 receptor deficiency: Deleting Ntrk2 in PVNTrkB neurons that project to the VMH (PVNTrkB→VMH neurons) or to the LPBN (PVHTrkB→LPBN neurons) induces hyperphagia and obesity, highlighting that these TrkB neuronal projections are critical for suppressing appetite [52].