Hasna et al. found that the overexpression of ORAI3 in BC led to a decrease in cell mortality and apoptosis, and an increase in resistance to apoptosis inducers and chemotherapeutic drugs through downregulation of the p53 tumor suppressor protein expression that was mediated by the pro-survival PI3K/Sgk–1/Sek–1 pathway [114]. The gene discussed is ORAI3; the disease is breast cancer.