In this sense, HMGB1 release from neurons, astroglia, and microglia can drive inflammation throughout activation of RAGE and TLR2-4 receptors, thus inducing activation of phenotypical changes in astrocytes cells characterized by the increase in intermediate filaments, associated to cellular hypertrophy, and the increase in the number of astrocytes, a process known as astrogliosis, which represents an early step in HD pathogenesis and neurodegeneration and pathogenesis [108,109,110]. The gene discussed is HMGB1; the disease is Huntington disease.