Since its description as a membrane-anchored protein which is able to recognize and transduce advanced glycation end-products (AGEs) [1], the receptor for advanced glycation end-products (RAGE) has emerged as a crucial contributor to many human pathologies such as diabetes, cardiovascular diseases, neurodegenerative diseases, autoimmunity disorders, and cancer among many others [2,3,4]. This evidence concerns the gene AGER and cardiovascular disorder.