An analysis of the protein coding region shows a slightly higher number of variants in Mitochondrially Encoded Cytochrome C Oxidase II (MT-CO2), Mitochondrially Encoded ATP Synthase Membrane Subunit 8 (MT-ATP8), and Mitochondrially Encoded Cytochrome B (MT-CYB) in ALS subjects compared to controls, but differences in the number of variants (p = 0.6290, chi-square test, Figure S5e, Table 4) and proportions of heteroplasmic/homoplasmic variants were not significantly different between the two groups (p = 0.5684, Fisher’s exact test, Figure S5e,f). The gene discussed is MT-CYB; the disease is amyotrophic lateral sclerosis.